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院长:王玉炯
2019-01-15   审核人:

王玉炯教授简介

 

王玉炯,宁夏大学二级教授、博士生导师,上海交通大学兼职教授、博士生导师。宁夏大学党委常委、生命科学学院院长、西部特色生物资源保护与利用教育部重点实验室主任。国家级教学名师、国务院政府特殊津贴获得者、“基础生物学”国家级教学团队带头人、教育部“长江学者与创新团队发展计划”创新团队带头人、中央联系的高级专家。

先后荣获全国模范教师、全国师德先进个人、国家“百千万人才工程”学术与技术带头人、教育部“跨世纪优秀人才”、“宝钢优秀教师特等奖”、自治区“塞上英才”、自治区“有突出贡献专业技术创新人才奖”、“100位为宁夏建设作出突出贡献英雄模范人物”、宁夏“十大杰出青年”、宁夏回族自治区先进工作者、宁夏大学建校五十周年突出贡献奖、宁夏大学科技创新工作特别贡献奖等奖励或荣誉称号。兼任教育部生物技术、生物工程类专业教学指导委员会副主任委员,宁夏回族自治区人民政府学位委员会委员,宁夏高等学校本科理工科类学科专业教学指导委员会主任委员,中国微生物学会理事,宁夏生物学会名誉理事长、宁夏大学学术委员会副主任委员、宁夏大学学术道德委员会副主任委员。《Vaccine》、《Molecules》等十余种国际杂志长期审稿人,《高校生物学教学研究(电子版)》副主编、《宁夏大学学报》(自然版)常务编委,《生命世界》、《生物学杂志》编委。

长期从事微生物学、分子生物学等学科的教学与科研工作。先后主持完成国家“863”计划项目、国家“973”计划项目、国家自然科学基金项目、国家科技攻关和科技支撑计划项目等国家级项目17项,省部级科技计划项目15项。获国家一类新药证书1项,获省部级科技进步一等奖2项、二等奖5项,申请国家发明专利4项,获国家级教学成果奖二等奖1项、自治区教学成果奖特等奖1项(以上奖项均为第一完成人)。在《Vaccine》、《Molecular Immunology》等国际期刊发表论文100余篇。曾多次应邀赴美国、日本、比利时等国家进行学术交流。

 

近期发表的主要论文:

 

1.       Xiaoling Wu, Jiamei Zhang, Chenjie Ma, Wu Li, Jin Zeng, Yujiong Wang, Guangcun Deng,∗∗A role for Wnt/β-catenin signalling in suppressing Bacillus Calmette-Guerininduced macrophage autophagy.Microbial Pathogenesis 127(2019)277-287        

2.       Yi Yang, Yingfei Sun, Jinrui Xu, Meihui Luo, Xiaoming Liuand Yujiong Wang*. Epithelial Cells Attenuate Toll-Like Receptor-Mediated Inflammatory Responses in onocyte-Derived Macrophage-Like Cells to Mycobacterium tuberculosis by Modulating the PI3K/Akt/mTOR Signaling Pathway.Mediators of Inflammation Volume 2018, Article ID 3685948, 19 pages        

3.       Di Xue, Yanan Li, Zhongjia Jiang, Guangcun Deng, Min Li, Xiaoming Liu, Yujiong Wang*. A ROS-dependent and Caspase-3-mediated apoptosis in sheep bronchial epithelial cells in response to Mycoplasma Ovipneumoniae infections. Veterinary Immunology and Immunopathology 187(2017)55-63        

4.       Zhongjia Jiang, Fuyang Song, Yanan Li, Di Xue, Guangcun Deng, Min Li, Xiaoming Liu and Yujiong Wang*. Capsular Polysaccharide is a Main Component of Mycoplasma ovipneumoniae in the Pathogen-Induced Toll-Like Receptor-Mediated Inflammatory Responses in Sheep Airway Epithelial Cells. Mediators of Inflammation  Volume 2017, Article ID 9891673, 15 pages          

5.       Zhongjia Jiang, Fuyang Song, Yanan Li, Di Xue, Guangcun Deng, Min Li, Xiaoming Liu* and Yujiong Wang*.Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.Oxidative Medicine and Cellular Longevity.Volume 2017, Article ID 6175841, 15 pages        

6.       Na Huang, Shuai Lu, Xiao-Ge Liu, Jie Zhu, Yujiong Wang*, and Rui-Tian Liu*. PLGA nanoparticles modified with a BBB-penetrating peptide co-delivering Aβ generation inhibitor and curcumin attenuate memory deficits and neuropathology in Alzheimer’s disease mice . Oncotarget, 2017, Vol. 8, (No. 46), pp: 81001-81013        

7.       Yanan Li, Zhongjia Jiang, Di Xue, Guangcun Deng, Min Li, Xiaoming Liu and Yujiong Wang*. Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway. BMC Microbiology (2016) 16:222  

8.       Xue D, Ma Y, Li M, Li Y, Luo H, Liu X, Wang Y*. Mycoplasma ovipneumoniae induces inflammatory response in sheep airway epithelial cells via a MyD88-dependent TLR signaling pathway. Veterinary Immunology and Immunopathology. 2015,163(1-2):57-66        

9.       Wu Li, Min Li, Guangcun Deng, Liping Zhao, Xiaoming Liu, Yujiong Wang *, Prime-boost vaccination with Bacillus Calmette Guerin and a recombinant adenovirus co-expressing CFP10, ESAT6, Ag                85A       and Ag85B of Mycobacterium tuberculosis induces robust antigen-specific immune responses in mice,  MOLECULAR MEDICINE REPORTS 2015,12: 3073-3080        

10.   Guangcun Deng, Wu Li, Xiaoling Wu, Shaowen Bao, Jin Zeng, Ning Zhao, Meihui Luo, Xiaoming Liua, Yujiong Wang*, Immunogenicity and protective efficacy of a recombinant adenoviral based vaccine expressing heat-stable enterotoxin (STa) and K99 adhesion antigen of enterotoxigenic Escherichia coli in mice. Molecular Immunology 2015, 68 (2): 684691.      

11.   Yi Yang, Jinrui Xu, Yujiong Wang*, Xiaoming Liu*. Polymorphic association of TCF 7L 2 gene with the susceptibility to type 2 diabetes mellitus in a Chinese Hui population.Genetics and Molecular Research, 2015, 14 (3): 10064-10071.    

12.   Xiaoling Wu, Guangcun Deng, Min Li, Yong Li, Chunyan Ma, Yujiong Wang* and Xiaoming Liu*, Wnt/β-Catenin signaling reduces Bacillus Calmette-Guerin-induced macrophage necrosis through a ROS -mediated PARP/AIF-dependent pathway, BMC Immunology, 2015, 16:16, doi: 10.1186 /s12865 -015- 0080- 5    

13.X. Zhou, C. Yang, Y. Li, X. Liu and Y. Wang*.  Potential of berberine to enhance antimicrobialactivity of commonly used antibiotics for dairy cow mastitis caused by multiple drug-resistant Staphylococcus epidermidis infection. Genetics and Molecular Research 14 (3): 9683-9692 (2015)        

14.   Chunyan Ma., Yong Li., Jin Zeng, Xiaoling Wu, Xiaoming Liu* and Yujiong Wang*. Mycobacterium bovis BCG Triggered MyD88 Induces miR-124 Feedback Negatively Regulates Immune Response in Alveolar Epithelial Cells, PLOS ONE, April 2014, Volume 9, Issue 4        

15.   Chunyan Ma, Yong Li, Min Li, Guangcun Deng, Xiaoling Wu, William C.S. Cho,Xiaoming Liu and Yujiong Wang. MicroRNA-124 negatively regulates TLR signaling in alveolarmacrophages in response to mycobacterial infection, Molecular Immunology, 62 (2014) 150–158

16.   Wu Li, Guangcun Deng, Min Li, Liping Zhao, Xiaoming Liu and Yujiong Wang. A recombinant adenovirus expressing CFP10, ESAT6, Ag                    85A         andAg85B of Mycobacterium tuberculosis elicits strong antigen-specificimmune responses in mice,Molecular Immunology, 62 (2014) 86–95  

17.   Xiaoling Wu , Guangcun Deng , Jin Zeng, Chunyan Ma , Xiaoming Liu* and Yujiong Wang *. A Caspase-Dependent Pathway Is Involved in Wnt/β-Catenin Signaling Promoted Apoptosis in Bacillus Calmette-Guerin Infected RAW264.7 Macrophages, Int. J. Mol. Sci. 2014, 15, 5045-5062  

18.   Peng-xin Xu, Shao-wei Wang, Xiao-lin Yu, Ya-jing Su, Yu-jiong Wang, Rui-tian Liu. Rutin improves spatial memory in Alzheimer’s disease transgenic mice by reducing A_ oligomer level and attenuating oxidative stress and neuroinflammation,Behavioural Brain Research ,264 (2014) 173–180

19.   Bo Yang, Xiaoming Liu, Min Li, Yi Yang and Yujiong Wang. Genetic Association of rs1800780 (AG) Polymorphism of the eNOS Gene with Susceptibility to Essential Hypertension in a Chinese Han Population, Biochem Genet (2014) 52:71–78 DOI 10.1007/s10528-013-9628-3

20.   J.X. Dai, X.M. Liu and Y.J. Wang,Diversity of endophytic bacteria inCaragana microphylla grown in the desert grassland of the Ningxia Hui Autonomous Region of China, Genetics and Molecular Research 13 (2): 2349-2358 (2014)

21.   Y. Yang, J.R. Xu, X.M. Liu, J. Zhou, M. Li and Y.J. Wang, Polymorphisms of +                2836 G       >A in the apoE gene are strongly associated with the susceptibility to essential hypertension in the Chinese Hui population, Genetics and Molecular Research 13 (1): 1212-1219 (2014)

22.   Yujiong Wang, Yong Li, Xiaoming Liu,* and William CS Cho,* Genetic and Epigenetic Studies for Determining Molecular Targets of Natural Product Anticancer Agents, Current Cancer Drug Targets, 2013, 13, 506-518

23.   Yujiong Wang, Guangcun Deng, Xiaoming Liu* and William C. Cho*. Monoclonal Antibodies in Lung Cancer, Expert Opinion in Biological Therapy, (2013) 13(2):209-226

24.   Guangcun Deng, Jin Zeng, Minjie Jian, Wenmiao Liu, Zhong Zhang, Xiaoming Liu and Yujiong Wang*. Nanoparticulated Heat-stable (STa) and Heat-labile B subunit (LTB) recombinant toxin improves vaccine protection against Enterotoxigenic Escherichia coli challenge in mouse, Journal Bioscience and Bioengineering, J Biosci Bioeng, 2013. 115(2): 147-153

25.   B. Yang, J.R. Xu, X.M. Liu, Y. Yang, M. Li and Y.J. Wang. Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population, Genetics and Molecular Research 12 (3): 3821-3829 (2013)      

26.   Miao Gao, Hui Yang, Ji Zhao, Jun Liu, Yu-jiong Wang*, Jian-guang Sun *. Paenibacillus brassicae sp. nov., isolated from cabbage rhizosphere in Beijing, China,  Antonie van Leeuwenhoek DOI 10.1007/s10482-012-9849-1      

27.   Xuezhang Zhou , Yuyan Zhang , Yong Li , Xiujing Hao , Xiaoming Liu*, and Yujiong Wang*, Azithromycin Synergistically Enhances Anti-Proliferative Activity of Vincristine in Cervical and Gastric Cancer Cells. Cancers.2012.4, 1318-1332  

28.   Wu Li, Guangcun Deng, Xiaoming Liu and Yujiong Wang*.Roles of Mucosal immunity in Mycobacteria infection, Tuberculosis Research and Treatment, 2012. 1-12. Article ID 791392    

29.   Jinxia Dai, Xiaoming Liu and Yujiong Wang*. Genetic diversity and Phylogeny of Rhizobia isolated from Caragana microphylia grown in desert soil of Ningxia in China, Genetic and Molecular Research, 2012. 11(3):2683-2693.

30.   Shao-wei Wang, Yu-Jiong Wang*, Ya-jing Su, Wei-wei Zhou, Shi-gao Yang, Ran Zhang, Min Zhao,Ya-Nan Li, Zi-ping Zhang, Da-wei Zhan, Rui-tian Liu. Rutin inhibits b-amyloid aggregation and cytotoxicity, attenuates oxidative stress, and decreases the production of nitric oxide and proinflammatory cytokines. Neuro Toxicology , 2012. 33(3): p. 482-90.    

31.   Xue, D., M. Zhao, Y.J. Wang*, Rui-tian Liu.et al. A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Abeta42-induced cytotoxicity and increasing microglial phagocytosis. Neurobiol Dis ,2012. 46:701-9    

32.   Xuezhang Zhou, Fang Jia and Yujiong Wang*. Total Alkaloids of Sophorea alopecuroides-induced down-regulation of AcrAB-ToLC efflux pump reverses susceptibility to Ciprofloxacin in clinical multidrug resistant Escherichia coli isolates.Phytotherapy Research, 2012. doi: 10.1002/ptr.4623.

33.   Yong Li, Yujiong Wang*and Xiaoming Liu*, The role of airway epithelial cells in response to Mycobacteria infection, Clinical and Developmental Immunology, 2012. 12: DOI: 10.1155/2012/791392

34.   Jinrui Xu, Yi Yang, Xiaoming Liu , Jingyin Sunand Yujiong Wang*. Genetic variation and significant association of polymorphism rs                    7700944 G         >A of TIM-4 gene with Rheumatoid Arthritis in the Chinese Hanand Hui Populations. International Journal of Immunogenetics, 2012. 39(5): 409-413.

35.   Xuezhang Zhou, Fang Jia, Xiaoming Liu , Cong Yang and Yujiong Wang*. Total Alkaloids from Kudouziincrease susceptibility of Extended-Spectrum b–Lactamases-producing Escherichia coli isolates to Cefotaxime and Ceftazidime.Chinese Journal of Integrative Medicine, 2012, 18(2): DOI:10.1007/S11655-01100899-4

36.   Jinrui Xu, Yi Yang, Xiaoming Liu , Jingyin Sunand Yujiong Wang*. Association of the Polymorphisms of TIM-1 Gene with Rheumatoid Arthritis in the Chinese Hui Minority Ethnic Population. Genetic and Molecular Research, 2012, 11(1): 61-69.

37.   Xuezhang Zhou, Li Zhao,Xiaoming Liu, Xueqiang Li, Fang Jia Yujiong Wang*. Antimycobacterial and synergistic effects of 18-β-glycyrrhetinic acid orglycyrrhetinic acid-30-piperazine in combination with isoniazid, rifampicin or streptomycin against Mycobacterium bovis. Phytotherapy Research, 2012, 26(2):253-258.

38.   Jinrui Xu, Yi Yang, Xiaoming Liu ,and Yujiong Wang*. The                      -1541 C         >T and +                    4259 G         >T of TIM-3 Polymorphisms are associated with Rheumatoid Arthritis in the Chinese Hui Population. International Journal of Immunogenetics, 2011, 38(6): 513-518.

39.   Xue-ting Du, Li Wang, Yu-jiong Wang*, Maria Andreasen, Da-wei Zhan, Ying Feng, Min Li, Min Zhao, Daniel Otzen, Di Xue, Yang Yang and Rui-tian Liu, A_1-16 Can Aggregate and Induce the Production of Reactive Oxygen Species, Nitric Oxide, and Inflammatory CytokinesJournal of Alzheimer’s Disease2011. 27(2): p. 401-13.      

40.   Xuezhang Zhou, Fang Jia,Xiaoming Liu, Jinhui Yang and Yujiong Wang*. In Vitro synergistic interaction of 5-O-methylglovanon and ampicillin againstampicillin resistant Staphylococcus aureus and Staphylococcus epidermidis isolates. Archives of Pharmacal Research, 2011,34(10):1751-1757.    

41.   Yong Li, Jing Wang, Haiyan He, Lingjie Ma, Jin Zeng, Xiaoming Liu, John F. Engelhardtand Yujiong Wang*. Immunohistochemical demonstration of airway epithelial cell markers of Guinea Pig. Tissue and Cell, 2011, 43(5):283-290.DOI: 10.1016/j.tice.2011.05.003    

42.   Jin Zeng, Guangcun Deng, Jing Wang, Jing Zhou, Xiaoming Liu, Qing Xie and Yujiong Wang*.Potential protective immunogenicity of recombinant Clostridium perfringensa- β2-β1 fusion toxin in mice, sows and cows. Vaccine, 2011, 29(33):5459-5466. DOI: 10.1016/j.    

43.   Ziping Zhang, Xiaoming Liu, Xu Zhang, Junhong Liu, Yanfang Hao, Xueyun Yang, and Yujiong Wang*.Comparative evaluation of the antioxidant effects of the natural vitamin C analog 2-O-β-D-glucopyranosyl-L-ascorbic acid isolated from Goji berry fruit. Archives of Pharmacal Research, 2011, 34(5):801-810, DOI: 10.1007/s12272-011-0514-4.

44.   Min Li, Chunji Ma, Xiaoming Liu, Dong Zhao, Qingchun Xuand Yujiong Wang*. Molecular cloning of HSP                70 in       Mycoplasma ovipeneumoniae and comparison with that of other mycoplasmas. Genetic and Molecular Research, 2011, 10(2): 834-848, DOI 10.4238/vol10-2gmr1193.      

45.   Xuezhang ZhouZhenwei SongXiaoming LiFang JiaYujiong Wang*. Production of Recombinant Porcine Interferon alpha Using PHB–Intein-Mediated Protein Purification Strategy. Appl Biochem Biotechnol. (2011) 163:981–993.

46.   Ziping Zhang, Xiaoming Liu, Tao Wu ,Junhong Liu, Xu Zhang,Xueyun Yang,Michael J.Goodheart, John F.Engelhardt, Yujiong Wang*.Selective suppression of cervical cancer Hela cells by 2-O-β-D-glucopyranosyl -L-ascorbic acid isolated from the fruit of Lycium barbarum L.Cell Biol Toxicol. (2011) 27:107-121

47.   Guangxian Xu, Hao Jia, Yong Li, Xiaoming Liu, Min Li, Yujiong Wang*. Hemolytic phospholipase Rv0183 of Mycobacterium tuberculosis induces inflammatory response and apoptosis in alveolar macrophage RAW264.7 cells. Can. J. Microbiol. 2010, 56: 916–924.

48.   Guangxian Xu,Yan Zhang,Hao Jia,Juan Li,Xiaoming Liu, John F. Engelhardt, Yujiong Wang*.Cloning and identification of microRNAs in bovine alveolar macrophages. Mol Cell Biochem.2009, 332:9-16.

49.   Wang XP, Zhang JH, Wang YJ*, Feng Y, Zhang X, Sun XX, Li JL, Du XT, Lambert MP, Yang SG, Zhao M, Klein WL, Liu RT*. Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers, FEBS Letters, 2009, 583:579-584.

50.   Ying Feng , Xiao-ping Wang, Yu-jiong Wang* , Xue-ting Dua, Xiao-xia Sun , Min Zhao, Lei Huang, Rui-tian Liu*,Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formation.Neuro Toxicology. 2009, 30:986-995.

 

 

 

 

注:“*”为通讯作者或并列第一作者

 

 

 

 

 

 

 

 

 

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