学习经历、社会兼职及获奖情况

徐金瑞，博士，教授，博士生导师。现任宁夏大学生命与学部副部长。主要研究方向为病原生物学与宿主免疫。主持完成国家自然科学基金项目2项，主持完成宁夏自然科学基金项目5项，在研宁夏自然科学基金项目1项。参与完成国家自然科学基金项目2项，教育部科学技术研究重点项目1项。在国内外学术期刊发表论文80余篇，其中以一作或通讯作者发表SCI论文18篇。宁夏生物分子检测学会理事，宁夏生物学会监事长。主讲的《遗传学》和《人类遗传探秘》课程分别获批国家级一流本科课程和自治区一流本科课程。先后荣获宁夏自然科学优秀学术论文一等奖1项、二等奖1项、三等奖1项。

代表性研究成果（近五年）

1.Runze Yang, Jinrui Xu*, Yaxin Wang*, Sheng Ye*. Structural definition of pseudorabies virus dUTPase reveals a novel folding dimer in the herpesvirus family. International Journal of Biological Macromolecules. 2024 Sep 14;280(Pt 1):135696. doi: 10.1016/j.ijbiomac.2024.135696. Epub ahead of print. PMID: 39284464.

2.Jiacong Sun, Congcong Chen, Pengpeng Pan, Keyi Zhang, Jinrui Xu* and Cheng Chen*. The potential of bacterial anti-phagocytic proteins in suppressing the clearance of extracellular vesicles mediated by host phagocytosis. Front Immunol. 2024 Jun 6;15:1418061. doi: 10.3389/fimmu.2024.1418061. PMID: 38903499; PMCID: PMC11186983.

3.Zhongxiang Ji, Binwu Bao, Yumei Wang, Zhengxing Wang, Yi Yang, Jinrui Xu, Xingping Wang*, and Zhuoma Luoreng*. RNA Sequencing Reveals the Involvement of Serum Exosomal miRNAs in Early Pregnancy in Cattle. Animals (Basel). 2024 Sep 6;14(17):2600. doi: 10.3390/ani14172600. PMID: 39272385; PMCID: PMC11394640.Zhongxiang Ji, Binwu Bao, Yumei Wang, Zhengxing Wang, Yi Yang,Jinrui Xu, Xingping Wang*, Zhuoma Luoreng*. RNA Sequencing Reveals the Involvement of Serum Exosomal miRNAs in Early Pregnancy in Cattle. Animals (Basel). 2024 Sep 6;14(17):2600. doi: 10.3390/ani14172600. PMID: 39272385; PMCID: PMC11394640.

4.Ma Boli, Xueyi Nie, Lei Liu, Mengyuan Li, Qi Chen, Yueyang Liu, Yuxin Hou, Yi Yang, andJinrui Xu*.2023. "GSK2656157, a PERK Inhibitor, Alleviates Pyroptosis of Macrophages Induced by Mycobacterium Bacillus Calmette–Guerin Infection" International Journal of Molecular Sciences. 2023, 24(22), 16239; https://doi.org/10.3390/ijms242216239

5.Mengyuan Li, Yueyang Liu, Xueyi Nie, Boli Ma, Yabo Ma, Yuxin Hou, Yi Yang,Jinrui Xu^*, and Yujiong Wang^*. 2023. S100A4 Promotes BCG-Induced Pyroptosis of Macrophages by Activating the NF-κB/NLRP3 Inflammasome Signaling Pathway International Journal of Molecular Sciences. 2023, 24(16), 12709; https://doi.org/10.3390/ijms241612709

6.Nie, Xueyi, Boli Ma, Lei Liu, Xiaotan Yuan, Mengyuan Li, Yueyang Liu, Yuxin Hou, Yi Yang,Jinrui Xu*, Yujiong Wang*. Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Guérin" International Journal of Molecular Sciences. 2023, 24(14), 11692; https://doi.org/10.3390/ijms241411692.

7.Chen Q, Zheng X, Li Y, Ma B, Nie X, Li M, Liu Y,Xu J*, Yang Y*. Wnt5a regulates autophagy in Bacille Calmette-Guérin (BCG)-Infected pulmonary epithelial cells. Microb Pathog. 2022 Oct 13;173(Pt A):105826. doi: 10.1016/j.micpath.2022.105826. Epub ahead of print. PMID: 36243383

8.Zheng X, Li M, Chen Q, Ma B, Nie X, Liu Y, Yang Y,Xu J*, Wang Y*. Ror2-mediated cholesterol accumulation regulates autophagic activity within BCG-infected macrophages. Microb Pathog. 2022 Jun;167:105564. doi: 10.1016/j.micpath.2022.105564. Epub 2022 May 7. PMID: 35537593.

9.Ma Y, Du C, Xie X, Zhang Y, Wang C,Xu J, Xia G, Yang Y. To explore the regulatory role of Wnt/P53/Caspase3 signal in mouse ovarian development based on LFQ proteomics. J Proteomics. 2023 Feb 10;272:104772. doi: 10.1016/j.jprot.2022.104772. Epub 2022 Nov 19. PMID: 36414229.

10.Zhang Y, Xie X, Ma Y, Du C, Jiao Y, Xia G,Xu J^*, Yang Y^*. Cyproterone Acetate Mediates IRE1α Signaling Pathway to Alleviate Pyroptosis of Ovarian Granulosa Cells Induced by Hyperandrogen. Biology (Basel). 2022 Dec 4;11(12):1761. doi: 10.3390/biology11121761. PMID: 36552271; PMCID: PMC9775519.

11.Jinrui Xu, Yuquan Yang, Zhaoyuan Hou, Hao Jia*, Yujiong Wang*, TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions.Theranostics 2021, 11(15)：7379-7390.

12.Jinrui Xu, Yanbin Zhou, Yi Yang, Cuiping Lv, Xiaoming Liu, Yujiong Wang. Involvement of ABC-transporters and acyltransferase 1 in intracellular cholesterol-mediated autophagy in bovine alveolar macrophages in response to the Bacillus Calmette-Guerin (BCG) infection. BMC Immunology (2020) 21:26. https://doi.org/10.1186/s12865-020-00356-x

13.Hao Yan, Jia Wen, Tuo Zhang, Wenying Zheng, Meina He, Kun Huang, Qirui Guo, Qian Chen, Yi Yang, Guangcun Deng,Jinrui Xu, Zhiqing Wei, Hua Zhang, Guoliang Xia , Chao Wang. Oocyte-derived E-cadherin acts as a multiple functional factor maintaining the primordial follicle pool in mice. cell death and disease. 2019 Feb 15;10(3):160